Turkish Airlines is expanding its Manchester- Istanbul service from 10-flights per week to 14.
The carrier, which has been flying from Manchester since 1993, said the extra flights would begin at the end of March.
It will operate Boeing 737-900 and Boeing 737-800 aircraft, with business and economy class available.
The flights will leave Manchester at 1100 or 1555 seven days a week.
The airline, which is a key partner of Manchester United FC, offers connections from Manchester to more than 100 destinations beyond Turkey.
Many business travellers use Istanbul as a hub for onward travel to the Far East, India, Africa, Central Asia and Russia.